Im attempting to request the next entire site 301 redirect:

word.something.blah.domain.com --> http://www.word.com

I'm not sure crafting the 301 redirect rule.

Can someone help?

I'll assume you're utilizing the same directory for everyone files on domain names. By which situation, a Redirect clause will not work (infinite redirect loop).

With mod_rewrite, you should check the need for the present HTTP_HOST and have a decision according to that:

RewriteEngine On

RewriteCond %{HTTP_HOST} ^([a-zA-Z0-9]+)\.something\.blah\.domain\.com$ [NC]
RewriteRule ^(.*)$ http://www.%1.com/$1 [R=301,NE,L]

put this into root directory from the subdomain:

Redirect permanent / http://www.word.com