<VirtualHost *:80>
ServerName mine.abc.def.edu
ProxyPassMatch ^(/.*\.aspx.*) http://mine.abc.def.edu:8080/$1

I'm running IIS on port 8080, and Apache on port 80. I've become the above mentioned within the apache config to effectively redirect ASP.Internet pages to IIS, however the images around the pages are missing. I believed I want some kind of Reverse Proxy rule that states "when the request the look or any other resource is from a aspx page, adding port 8080", but I am unsure how to do this.

Do you need another virtual host title, or subdirectory, for that IIS server? That method for you to match around the host header inside your mod_proxy setup.