Searching through my website stats I am realizing a lot of hits on my small wordpress/xmlrpc.php file. It isn't from me afaik, should i be worried about something here, can there be anyway to secure this?

I am running multiple wordpress sites on a single apache2, and it is only one of these this is going on to.

If you do not make use of the xmlrpc interface (pingbacks or blogging from exterior sources like android/apple iphone), you are able to switch off this feature. Configurations -> Writing -> XML-RPC

I installed "Home windows Live Author" on a single of my very novice clients. It's good for posts. It's very easy and does a great job. It requires XML-RPC.